Neem powder is a natural powder made from the leaves of the neem tree. It is a popular home remedy in many parts of the world and has been used for centuries in India, Africa, and other parts of Asia for its medicinal and healing properties. Neem powder has been used to treat skin ailments, digestive issues, infections, and even cancer. neem powder is made by drying and grinding the leaves of the neem tree, then sifting the powder into a fine, light powder. It has a slightly bitter taste and a strong smell, but the odor dissipates as the powder is mixed with other ingredients.